Wretchedest

adjective

1. Very miserable; feeling deep affliction or distress.

   "I felt wretched after my wife died."

2. Worthless; paltry; very poor or mean; miserable.

   "The street was full of wretched beggars dressed in rags."

3. Hatefully contemptible; despicable; wicked.
4. Used to express dislike of or annoyance towards the mentioned thing.

   "Will you please stop playing that wretched trombone!"