Knockdowns

noun

1. An act of knocking down or the condition of being knocked down.
2. An overwhelming blow.
3. Very strong ale or beer.
4. A genetically modified organism that carries one or more genes in its chromosomes that have been made less active or had their expression reduced.
5. The use of a reagent such as an oligonucleotide with sequence complementary to an active gene or its mRNA transcript, to interfere with the expression of said gene.